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Timothy P Dalton Selected Research

Cytochrome P-450 CYP1A2 (CYP1A2)

7/2006For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
5/2005Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
2/2005Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
2/2003Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
1/2003Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.
11/2002Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor.
5/2002Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.
4/2002Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

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Timothy P Dalton Research Topics

Disease

5Carcinogenesis
12/2006 - 08/2003
5Neoplasms (Cancer)
05/2005 - 01/2003
2Liver Diseases (Liver Disease)
12/2010 - 05/2007
2Necrosis
04/2007 - 03/2005
2Cleft Palate (Palate, Cleft)
07/2006 - 02/2006
2Hydronephrosis
07/2006 - 02/2006
2Hypertrophy
04/2006 - 05/2004
2Atrophy
04/2006 - 05/2004
2Inflammation (Inflammations)
01/2006 - 09/2002
2Body Weight (Weight, Body)
07/2005 - 11/2002
2Porphyria Cutanea Tarda
02/2003 - 04/2002
2Hepatocellular Carcinoma (Hepatoma)
02/2003 - 05/2002
1Liver Cirrhosis (Hepatic Cirrhosis)
12/2010
1Lung Injury
05/2010
1Schizophrenia (Dementia Praecox)
02/2010
1Teratogenesis
07/2006
1Congenital Abnormalities (Deformity)
07/2006
1Infections
07/2006
1Acute Lung Injury
01/2006
1Hypoxia (Hypoxemia)
11/2005
1Acute Promyelocytic Leukemia
10/2005
1Multiple Myeloma
10/2005
1Urinary Bladder Neoplasms (Bladder Cancer)
10/2005
1Iron Overload
05/2005
1Leukopenia
05/2004
1Wasting Syndrome (Wasting Disease)
05/2004
1Gingival Overgrowth
04/2003
1Methemoglobinemia
05/2002

Drug/Important Bio-Agent (IBA)

8Cytochrome P-450 CYP1A2 (CYP1A2)IBA
07/2006 - 04/2002
6AntioxidantsIBA
12/2010 - 09/2002
6Cytochrome P-450 CYP1A1 (CYP1A1)IBA
07/2006 - 11/2002
4Glutathione (Reduced Glutathione)IBA
12/2010 - 05/2007
4EnzymesIBA
12/2006 - 09/2002
4Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
07/2006 - 06/2004
3CadmiumIBA
04/2007 - 03/2005
3Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
12/2006 - 09/2002
3DioxinsIBA
07/2006 - 11/2002
2DNA (Deoxyribonucleic Acid)IBA
12/2006 - 05/2004
2Benzo(a)pyreneIBA
04/2006 - 05/2004
2Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
04/2006 - 05/2004
2Polychlorinated Dibenzodioxins (TCDD)IBA
07/2005 - 05/2004
2IronIBA
05/2005 - 04/2002
1Acetylcysteine (Siran)FDA LinkGeneric
12/2010
1OzoneIBA
05/2010
1ParvalbuminsIBA
02/2010
1Complementary DNA (cDNA)IBA
07/2006
1IgA receptor (protein B)IBA
01/2006
1MetallothioneinIBA
01/2006
1Proteins (Proteins, Gene)FDA Link
01/2006
1NickelIBA
01/2006
1Surface-Active Agents (Surfactants)IBA
01/2006
1ZincIBA
01/2006
1Transcription Factor MTF-1IBA
11/2005
1Oxygen (Dioxygen)IBA
11/2005
1ArsenicIBA
10/2005
1Arsenic Trioxide (Trisenox)FDA Link
10/2005
1Hazardous Substances (Hazardous Materials)IBA
10/2005
1Glutathione Disulfide (GSSG)FDA LinkGeneric
07/2005
1Superoxides (Superoxide)IBA
07/2005
1Succinic Acid (Succinate)IBA
07/2005
1LigandsIBA
05/2005
1Polychlorinated Biphenyls (PCBs)IBA
05/2005
1Heme (Haem)IBA
05/2005
1Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)IBA
05/2005
1Cytochrome P450 Family 1IBA
06/2004
1LipidsIBA
05/2004
1HerbicidesIBA
11/2003
1alachlorIBA
11/2003
1CarcinogensIBA
08/2003
14-biphenylamineIBA
08/2003
1DNA AdductsIBA
08/2003
1Dental Impression MaterialsIBA
04/2003
1methoxyresorufin-O-demethylaseIBA
02/2003
1Corn Oil (Oil, Corn)IBA
11/2002
1MethemoglobinIBA
05/2002
12-tert-butylhydroquinone (tert-butylhydroquinone)IBA
05/2002